Leptin regulates striatal regions and human eating behavior.
Ontology highlight
ABSTRACT:
SUBMITTER: Farooqi IS
PROVIDER: S-EPMC3838941 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
Leptin regulates striatal regions and human eating behavior.
Farooqi I Sadaf IS Bullmore Edward E Keogh Julia J Gillard Jonathan J O'Rahilly Stephen S Fletcher Paul C PC
Science (New York, N.Y.) 20070809 5843
Studies of the fat-derived hormone leptin have provided key insights into the molecular and neural components of feeding behavior and body weight regulation. An important challenge lies in understanding how the rewarding properties of food interact with, and can override, physiological satiety signals and promote overeating. We used functional magnetic resonance imaging to measure brain responses in two human patients with congenital leptin deficiency who were shown images of food before and aft ...[more]
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