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Single-step injection of gold nanoparticles through phospholipid membranes.


ABSTRACT: We propose and demonstrate a new method of an all-optical, contactless, one-step injection of single gold nanoparticles through phospholipid membranes. The method is based on the combination of strong optical forces acting on and simultaneous optical heating of a gold nanoparticle exposed to laser light tuned to the plasmon resonance of the nanoparticle. A focused laser beam captures single nanoparticles from the colloidal suspension, guides them toward a phospholipid vesicle and propels them through the gel-phase membrane, resulting in the nanoparticle internalization into the vesicle. Efficient resonant optical heating of the gold nanoparticle causes a pore to form in the gel-phase membrane, a few-hundred nanometers in size, which remains open for several minutes.

SUBMITTER: Urban AS 

PROVIDER: S-EPMC3839078 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Single-step injection of gold nanoparticles through phospholipid membranes.

Urban Alexander S AS   Pfeiffer Tom T   Fedoruk Michael M   Lutich Andrey A AA   Feldmann Jochen J  

ACS nano 20110419 5


We propose and demonstrate a new method of an all-optical, contactless, one-step injection of single gold nanoparticles through phospholipid membranes. The method is based on the combination of strong optical forces acting on and simultaneous optical heating of a gold nanoparticle exposed to laser light tuned to the plasmon resonance of the nanoparticle. A focused laser beam captures single nanoparticles from the colloidal suspension, guides them toward a phospholipid vesicle and propels them th  ...[more]

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