Ontology highlight
ABSTRACT:
SUBMITTER: Harland DR
PROVIDER: S-EPMC3839254 | biostudies-literature | 2012 Aug-Sep
REPOSITORIES: biostudies-literature
Prostaglandins, leukotrienes, and essential fatty acids 20120802 2-3
The chick chorioallantoic membrane (CAM) subserves gas exchange in the developing embryo and shell-less culture affords a unique opportunity for direct observations over time of individual blood vessels to pharmacologic interventions. We tested a number of lipids including prostaglandins PGE(1&2) for vascular effects and signaling in the CAM. Application of PGE(1&2) induced a decrease in the diameter of large blood vessels and a concentration-dependent, localized, reversible loss of blood flow t ...[more]