Ontology highlight
ABSTRACT:
SUBMITTER: Gerhart-Hines Z
PROVIDER: S-EPMC3839416 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Gerhart-Hines Zachary Z Feng Dan D Emmett Matthew J MJ Everett Logan J LJ Loro Emanuele E Briggs Erika R ER Bugge Anne A Hou Catherine C Ferrara Christine C Seale Patrick P Pryma Daniel A DA Khurana Tejvir S TS Lazar Mitchell A MA
Nature 20131027 7476
Circadian oscillation of body temperature is a basic, evolutionarily conserved feature of mammalian biology. In addition, homeostatic pathways allow organisms to protect their core temperatures in response to cold exposure. However, the mechanism responsible for coordinating daily body temperature rhythm and adaptability to environmental challenges is unknown. Here we show that the nuclear receptor Rev-erbα (also known as Nr1d1), a powerful transcriptional repressor, links circadian and thermoge ...[more]