Ontology highlight
ABSTRACT:
SUBMITTER: Pottekat A
PROVIDER: S-EPMC3839581 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Pottekat Anita A Becker Scott S Spencer Kathryn R KR Yates John R JR Manning Gerard G Itkin-Ansari Pamela P Balch William E WE
Cell reports 20130905 5
Insulin homeostasis in pancreatic β cells is now recognized as a critical element in the progression of obesity and type II diabetes (T2D). Proteins that interact with insulin to direct its sequential synthesis, folding, trafficking, and packaging into reserve granules in order to manage release in response to elevated glucose remain largely unknown. Using a conformation-based approach combined with mass spectrometry, we have generated the insulin biosynthetic interaction network (insulin BIN), ...[more]