Sortilin receptor 1 predicts longitudinal cognitive change.
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ABSTRACT:
SUBMITTER: Reynolds CA
PROVIDER: S-EPMC3839667 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
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Sortilin receptor 1 predicts longitudinal cognitive change.
Reynolds Chandra A CA Zavala Catalina C Gatz Margaret M Vie Loryana L Johansson Boo B Malmberg Bo B Ingelsson Erik E Prince Jonathan A JA Pedersen Nancy L NL
Neurobiology of aging 20130111 6
The gene encoding sortilin receptor 1 (SORL1) has been associated with Alzheimer's disease risk. We examined 15 SORL1 variants and single nucleotide polymorphism (SNP) set risk scores in relation to longitudinal verbal, spatial, memory, and perceptual speed performance, testing for age trends and sex-specific effects. Altogether, 1609 individuals from 3 population-based Swedish twin studies were assessed up to 5 times across 16 years. Controlling for apolipoprotein E genotype (APOE), multiple si ...[more]
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