Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3839694 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Li Yang Y Gao Junyuan J Lu Zhongju Z McFarland Kelli K Shi Jingyi J Bock Kevin K Cohen Ira S IS Cui Jianmin J
Proceedings of the National Academy of Sciences of the United States of America 20131104 47
Gating of ion channels by ligands is fundamental to cellular function, and ATP serves as both an energy source and a signaling molecule that modulates ion channel and transporter functions. The slowly activating K(+) channel I(Ks) in cardiac myocytes is formed by KCNQ1 and KCNE1 subunits that conduct K(+) to repolarize the action potential. Here we show that intracellular ATP activates heterologously coexpressed KCNQ1 and KCNE1 as well as I(Ks) in cardiac myocytes by directly binding to the C te ...[more]