Ontology highlight
ABSTRACT:
SUBMITTER: Batchelor TT
PROVIDER: S-EPMC3839699 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Batchelor Tracy T TT Gerstner Elizabeth R ER Emblem Kyrre E KE Duda Dan G DG Kalpathy-Cramer Jayashree J Snuderl Matija M Ancukiewicz Marek M Polaskova Pavlina P Pinho Marco C MC Jennings Dominique D Plotkin Scott R SR Chi Andrew S AS Eichler April F AF Dietrich Jorg J Hochberg Fred H FH Lu-Emerson Christine C Iafrate A John AJ Ivy S Percy SP Rosen Bruce R BR Loeffler Jay S JS Wen Patrick Y PY Sorensen A Greg AG Jain Rakesh K RK
Proceedings of the National Academy of Sciences of the United States of America 20131104 47
Antiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of the mechanisms of action of antiangiogenic agents has hindered optimization and broader application of this new therapeutic modality. In particular, the impact of antiangiogenic therapy on tumor blood flow and oxygenation status (i.e., the role of vessel pruning versus normalization) remains controversial. This controversy has become critical as multiple ...[more]