Ontology highlight
ABSTRACT:
SUBMITTER: Glahn DC
PROVIDER: S-EPMC3839730 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Glahn David C DC Kent Jack W JW Sprooten Emma E Diego Vincent P VP Winkler Anderson M AM Curran Joanne E JE McKay D Reese DR Knowles Emma E EE Carless Melanie A MA Göring Harald H H HH Dyer Thomas D TD Olvera Rene L RL Fox Peter T PT Almasy Laura L Charlesworth Jac J Kochunov Peter P Duggirala Ravi R Blangero John J
Proceedings of the National Academy of Sciences of the United States of America 20131104 47
Identification of genes associated with brain aging should markedly improve our understanding of the biological processes that govern normal age-related decline. However, challenges to identifying genes that facilitate successful brain aging are considerable, including a lack of established phenotypes and difficulties in modeling the effects of aging per se, rather than genes that influence the underlying trait. In a large cohort of randomly selected pedigrees (n = 1,129 subjects), we documented ...[more]