Ontology highlight
ABSTRACT:
SUBMITTER: Yoshimatsu Y
PROVIDER: S-EPMC3839734 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Yoshimatsu Yasuhiro Y Lee Yulia G YG Akatsu Yuichi Y Taguchi Luna L Suzuki Hiroshi I HI Cunha Sara I SI Maruyama Kazuichi K Suzuki Yuka Y Yamazaki Tomoko T Katsura Akihiro A Oh S Paul SP Zimmers Teresa A TA Lee Se-Jin SJ Pietras Kristian K Koh Gou Young GY Miyazono Kohei K Watabe Tetsuro T
Proceedings of the National Academy of Sciences of the United States of America 20131016 47
Lymphatic vessels (LVs) play critical roles in the maintenance of fluid homeostasis and in pathological conditions, including cancer metastasis. Although mutations in ALK1, a member of the transforming growth factor (TGF)-β/bone morphogenetic protein (BMP) receptor family, have been linked to hereditary hemorrhagic telangiectasia, a human vascular disease, the roles of activin receptor-like kinase 1 (ALK-1) signals in LV formation largely remain to be elucidated. We show that ALK-1 signals inhib ...[more]