The response of carotid intima-media thickness to medical treatment is correlated with that of intracranial atherosclerosis.

ABSTRACT:

Background and purpose

Intracranial atherosclerotic stenosis (ICAS) is considered as a major cause of stroke. The carotid intima-media thickness (CIMT), which accurately reflects the burden of generalized atherosclerosis, is also associated with stroke. The aim of this study was to determine the association between the CIMT and ICAS responses to medical treatment.

Methods

This study constituted part of the "Trial of cilostazol in symptomatic intracranial arterial stenosis"-2 that evaluated the ICAS response after randomized antiplatelet treatment. Magnetic resonance angiography and CIMT measurement were performed at baseline and after 7 months of treatment. CIMT was measured using semiautomated software, and was presented as maximum (CIMT-max) and average (CIMT-ave) values.

SUBMITTER: Kwon SU 

PROVIDER: S-EPMC3840133 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature