Dataset Information

A cross-sectional study of factors associated with uptake of vaccination against influenza among older residents in the postpandemic season in Beijing, China.

ABSTRACT:

Objective

Annually, influenza epidemics are associated with high mortality rates, notably among elderly persons. The aim of the study was to examine the level of influenza vaccine coverage among Chinese residents aged 60 years and older and to examine the demographic, behavioural and lifestyle health factors associated with vaccine receipt.

Design

Cross-sectional study.

Setting

Beijing, China.

Participants

Stratified sampling was used to recruit participants for this study. A total of 2578 people aged 60 years and older consented to participate in this study. Questionnaires from 2481 participants were valid and were included in the final analysis.

Outcome measures

Influenza vaccination status and factors associated with vaccination.

Methods

In late 2010, a survey was conducted with residents from three urban and three rural districts in Beijing, China. Multivariate logistic regression was performed to detect the factors associated with influenza vaccination.

Results

2481 older people (aged ≥60 years) were included in the final analysis. In 2010, 44% had received the annual influenza vaccine. Lower education level, poor health status of the participant, regular taking exercises and considering that vaccine is the best measure for preventing influenza were associated with influenza vaccination coverage.

Conclusions

Influenza vaccine coverage in Beijing still remains suboptimal. Further work needs to be undertaken to ascertain whether the methods used to distribute the vaccine are adequate and whether health professionals are appropriately promoting the vaccine.

SUBMITTER: Zheng Y

PROVIDER: S-EPMC3840337 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

A cross-sectional study of factors associated with uptake of vaccination against influenza among older residents in the postpandemic season in Beijing, China.

Zheng Yang Y Yang Peng P Wu Shuangsheng S Ma Chunna C Seale Holly H Macintyre C Raina CR Wang Quanyi Q

BMJ open 20131120 11

<h4>Objective</h4>Annually, influenza epidemics are associated with high mortality rates, notably among elderly persons. The aim of the study was to examine the level of influenza vaccine coverage among Chinese residents aged 60 years and older and to examine the demographic, behavioural and lifestyle health factors associated with vaccine receipt.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>Beijing, China.<h4>Participants</h4>Stratified sampling was used to recruit participants for this ...[more]

PMID: 24259387

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Project description:We analyzed the clinical characteristics of outpatients with influenza-B-associated pneumonia during the 2021-2022 influenza season and analyzed the molecular epidemiology and evolution of influenza B virus. The presence of influenza B virus was confirmed by reverse transcription polymerase chain reaction (RT-PCR). Electronic medical records were used to collect and analyze data of outpatients. The HA and NA genes were phylogenetically analyzed using ClustalW 2.10 and MEGA 11.0. Out of 1569 outpatients who tested positive for influenza B virus, 11.7% (184/1569) developed pneumonia, and of these, 19.0% (35/184) had underlying diseases. Fever, cough, and sore throat were the most common symptoms. Among the complications, acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), and shock accounted for 2.7% (5/184), 4.9% (9/184), and 1.6% (3/184), respectively. Of the outpatients, 2.7% (5/184) were admitted to the hospital, and 0.5% (1/184) of them died. All of the strains from Beijing were identified as belonging to the B/Victoria lineage. The HA and NA gene sequences of 41 influenza B viruses showed high similarity to each other, and all of them belonged to clade 1A.3. Compared with the vaccine strain B/Washington/02/2019, all of the isolates contained N150K, G181E, and S194D mutations. S194D, E195K, and K200R mutations were detected in the 190 helix of the receptor binding region of HA. Co-mutations of H122Q, A127T, P144L, N150K, G181E, S194D, and K200R in HA and D53N, N59S, and G233E in NA were detected in 78.0% (32/41) of the isolates, and 56.3% (18/32) of these were from outpatients with influenza-B-associated pneumonia. Influenza outpatients with underlying diseases were more likely to develop pneumonia. No significant differences were observed in clinical symptoms or laboratory results between outpatients with and without pneumonia, so testing for influenza virus seems to be a good choice. The observed amino acid variations suggest that current vaccines might not provide effective protection.

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Dataset Information

A cross-sectional study of factors associated with uptake of vaccination against influenza among older residents in the postpandemic season in Beijing, China.

Objective

Design

Setting

Participants

Outcome measures

Methods

Results

Conclusions

Publications

A cross-sectional study of factors associated with uptake of vaccination against influenza among older residents in the postpandemic season in Beijing, China.

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