Dataset Information

Geographical prevalence and risk factors for pterygium: a systematic review and meta-analysis.

ABSTRACT:

Objective

Pterygium is considered to be a proliferative overgrowth of bulbar conjunctiva that can induce significant astigmatism and cause visual impairment; this is the first meta-analysis to investigate the pooled prevalence and risk factors for pterygium in the global world.

Design

A systematic review and meta-analysis of population-based studies.

Setting

International.

Participants

A total of 20 studies with 900 545 samples were included.

Primary outcome measure

The pooled prevalence and risk factors for pterygium.

Results

20 studies were included. The pooled prevalence of pterygium was 10.2% (95% CI 6.3% to 16.1%). The pooled prevalence among men was higher than that among women (14.5% vs 13.6%). The proportion of participants with unilateral cases of pterygium was higher than that of participants with bilateral cases of pterygium. We found a trend that the higher pooled prevalence of pterygium was associated with decreasing geographical latitude and age in the world. The pooled OR was 2.32 (95% CI 1.66 to 3.23) for the male gender and 1.76 (95% CI 1.55 to 2.00) for outdoor activity, respectively.

Conclusions

The pooled prevalence of pterygium was relatively high, especially for low latitude regions and the elderly. There were many modifiable risk factors associated with pterygium to which healthcare providers should pay more attention.

SUBMITTER: Liu L

PROVIDER: S-EPMC3840351 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Geographical prevalence and risk factors for pterygium: a systematic review and meta-analysis.

Liu Lei L Wu Jingyang J Geng Jin J Yuan Zhe Z Huang Desheng D

BMJ open 20131119 11

<h4>Objective</h4>Pterygium is considered to be a proliferative overgrowth of bulbar conjunctiva that can induce significant astigmatism and cause visual impairment; this is the first meta-analysis to investigate the pooled prevalence and risk factors for pterygium in the global world.<h4>Design</h4>A systematic review and meta-analysis of population-based studies.<h4>Setting</h4>International.<h4>Participants</h4>A total of 20 studies with 900 545 samples were included.<h4>Primary outcome measu ...[more]

PMID: 24253031

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Project description:Diabetic retinopathy (DR), the primary retinal vascular complication of diabetes mellitus (DM), is a leading cause of vision impairment and blindness in working-age population globally. Despite mounting concerns about the emergence of DM as a major public health problem in the largest developing country, China, much remains to be understood about the epidemiology of DR. We aimed to investigate the prevalence of and risk factors for DR, and estimate the burden of DR in China in 2010.China National Knowledge Infrastructure (CNKI), Wanfang, Chinese Biomedicine Literature Database (CBM-SinoMed), PubMed, Embase and Medline were searched for studies that reported the prevalence of and risk factors for DR in Chinese population between 1990 and 2017. A random-effects meta-analysis model was adopted to pool the overall prevalence of DR. Variations in the prevalence of DR in different age groups, DM duration groups and settings were assessed by subgroup meta-analysis and meta-regression. Odds ratios (ORs) of major risk factors were pooled using random-effects meta-analysis. The number of people with DR in 2010 was estimated by multiplying the age-specific prevalence of DR in people with DM with the corresponding number of people with DM in China. Finally, the national number of people with DR was distributed into six geographic regions using a risk factor-based model.A total of 31 studies provided information on the prevalence of DR and 21 explored potential risk factors for DR. The pooled prevalence of any DR, nonproliferative DR (NPDR) and proliferative DR (PDR) was 1.14% (95% CI?=?0.80-1.52), 0.90% (95% CI?=?0.56-1.31) and 0.07% (95% CI?=?0.02-0.14) in general population; In people with DM, the pooled prevalence rates were 18.45% (95% CI?=?14.77-22.43), 15.06% (95% CI?=?11.59-18.88) and 0.99% (95% CI?=?0.40-1.80) for any DR, NPDR and PDR, respectively. The prevalence of any DR in DM patients peaked between 60 and 69 years of age, and increased steeply with the duration of DM. DM patients residing in rural China were at a higher risk to have DR than those in urban areas. In addition, insulin treatment, elevated FBG level and higher HbA1c concentration were confirmed to be associated with a higher prevalence of DR in people with DM, with meta-ORs of 1.99 (95% CI?=?1.34-2.95), 1.33 (95% CI?=?1.12-1.59) and 1.15 (95% CI?=?1.09-1.20) respectively. In 2010, a total of 13.16 million (95% CI?=?8.95-18.00) Chinese aged 45 years and above were living with DR, among whom the most were in South Central China and the least were in Northwest China.DR has become a serious public health problem in China. Optimal screening of and interventions on DR should be implemented. Improved epidemiological studies on DR are still required.

Dataset Information

Geographical prevalence and risk factors for pterygium: a systematic review and meta-analysis.

Objective

Design

Setting

Participants

Primary outcome measure

Results

Conclusions

Publications

Geographical prevalence and risk factors for pterygium: a systematic review and meta-analysis.

Similar Datasets

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