Ontology highlight
ABSTRACT:
SUBMITTER: Koritzinsky M
PROVIDER: S-EPMC3840938 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Koritzinsky Marianne M Levitin Fiana F van den Beucken Twan T van den Beucken Twan T Rumantir Ryan A RA Harding Nicholas J NJ Chu Kenneth C KC Boutros Paul C PC Braakman Ineke I Wouters Bradly G BG
The Journal of cell biology 20131118 4
Most proteins destined for the extracellular space require disulfide bonds for folding and stability. Disulfide bonds are introduced co- and post-translationally in endoplasmic reticulum (ER) cargo in a redox relay that requires a terminal electron acceptor. Oxygen can serve as the electron acceptor in vitro, but its role in vivo remains unknown. Hypoxia causes ER stress, suggesting a role for oxygen in protein folding. Here we demonstrate the existence of two phases of disulfide bond formation ...[more]