Ontology highlight
ABSTRACT:
SUBMITTER: Brafman DA
PROVIDER: S-EPMC3841266 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Brafman David A DA Moya Noel N Allen-Soltero Stephanie S Fellner Thomas T Robinson Megan M McMillen Zoë L ZL Gaasterland Terry T Willert Karl K
Stem cell reports 20131031 5
SOX2 is involved in several cell and developmental processes, including maintenance of embryonic stem cells, differentiation of neural progenitor cells, and patterning of gut endoderm. To study its role in a human system, we generated a human embryonic stem cell (hESC) line harboring a reporter gene encoding GFP in the SOX2 locus. This SOX2 reporter line faithfully recapitulates expression of the SOX2 gene in undifferentiated human pluripotent stem cells (hPSCs), neural progenitor cells (NPCs), ...[more]