Ontology highlight
ABSTRACT:
SUBMITTER: Joly W
PROVIDER: S-EPMC3841267 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Joly Willy W Chartier Aymeric A Rojas-Rios Patricia P Busseau Isabelle I Simonelig Martine M
Stem cell reports 20131107 5
Translational regulation plays an essential role in Drosophila ovarian germline stem cell (GSC) biology. GSC self-renewal requires two translational repressors, Nanos (Nos) and Pumilio (Pum), which repress the expression of differentiation factors in the stem cells. The molecular mechanisms underlying this translational repression remain unknown. Here, we show that the CCR4 deadenylase is required for GSC self-renewal and that Nos and Pum act through its recruitment onto specific mRNAs. We ident ...[more]