Ontology highlight
ABSTRACT:
SUBMITTER: Nalls MA
PROVIDER: S-EPMC3841974 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Nalls Michael A MA Duran Raquel R Lopez Grisel G Kurzawa-Akanbi Marzena M McKeith Ian G IG Chinnery Patrick F PF Morris Christopher M CM Theuns Jessie J Crosiers David D Cras Patrick P Engelborghs Sebastiaan S De Deyn Peter Paul PP Van Broeckhoven Christine C Mann David M A DM Snowden Julie J Pickering-Brown Stuart S Halliwell Nicola N Davidson Yvonne Y Gibbons Linda L Harris Jenny J Sheerin Una-Marie UM Bras Jose J Hardy John J Clark Lorraine L Marder Karen K Honig Lawrence S LS Berg Daniela D Maetzler Walter W Brockmann Kathrin K Gasser Thomas T Novellino Fabiana F Quattrone Aldo A Annesi Grazia G De Marco Elvira Valeria EV Rogaeva Ekaterina E Masellis Mario M Black Sandra E SE Bilbao Juan M JM Foroud Tatiana T Ghetti Bernardino B Nichols William C WC Pankratz Nathan N Halliday Glenda G Lesage Suzanne S Klebe Stephan S Durr Alexandra A Duyckaerts Charles C Brice Alexis A Giasson Benoit I BI Trojanowski John Q JQ Hurtig Howard I HI Tayebi Nahid N Landazabal Claudia C Knight Melanie A MA Keller Margaux M Singleton Andrew B AB Wolfsberg Tyra G TG Sidransky Ellen E
JAMA neurology 20130601 6
<h4>Importance</h4>While mutations in glucocerebrosidase (GBA1) are associated with an increased risk for Parkinson disease (PD), it is important to establish whether such mutations are also a common risk factor for other Lewy body disorders.<h4>Objective</h4>To establish whether GBA1 mutations are a risk factor for dementia with Lewy bodies (DLB). DESIGN We compared genotype data on patients and controls from 11 centers. Data concerning demographics, age at onset, disease duration, and clinical ...[more]