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Nanovector delivery of siRNA for cancer therapy.

ABSTRACT: RNA interference holds the promise to knock down expression of every cancer gene. Both academic laboratories and pharmaceutical companies have committed heavily on manpower and financial resources to develop small interfering RNA (siRNA) cancer therapeutics over the last decade. Although significant advances have been made in the design of siRNA therapeutics and mechanism of action on cancer cell killing, there are still many hurdles to overcome including effective delivery of therapeutics in vivo. Nanotechnology has had an important role in the development of delivery vectors so far. This article summarizes current nanovectors for siRNA delivery, discusses technical challenges in overcoming biological barriers, and introduces the multistage vector system for tumor-specific delivery.

SUBMITTER: Shen H

PROVIDER: S-EPMC3842228 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Nanovector delivery of siRNA for cancer therapy.

Shen H H Sun T T Ferrari M M

Cancer gene therapy 20120504 6

RNA interference holds the promise to knock down expression of every cancer gene. Both academic laboratories and pharmaceutical companies have committed heavily on manpower and financial resources to develop small interfering RNA (siRNA) cancer therapeutics over the last decade. Although significant advances have been made in the design of siRNA therapeutics and mechanism of action on cancer cell killing, there are still many hurdles to overcome including effective delivery of therapeutics in vi ...[more]

PMID: 22555511

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