CD36 haplotypes are associated with lipid profile in normal-weight subjects.

ABSTRACT:

Background

Dyslipidemia is a common metabolic disorder that may result from abnormalities in the synthesis, processing and catabolism of lipoprotein particles. Disorders of lipoprotein concentrations and elevated concentration of oxidized lipoproteins (oxLDL) are risk factors in the pathogenesis of cardiovascular diseases (CVD). CD36 plays an important role in lipid metabolism and polymorphisms in the CD36 gene are related to cardiovascular risk factors. The purpose of this study was to evaluate whether there is an association between genotypes and haplotypes of five polymorphisms in the CD36 gene with lipid levels in young normal-weight subjects.

Methods

A total of 232 unrelated subjects with normal-weight of 18 to 25 years old (157 women and 75 men) were randomly selected.

SUBMITTER: Ramos-Arellano LE 

PROVIDER: S-EPMC3842800 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature