Ontology highlight
ABSTRACT:
SUBMITTER: Lim D
PROVIDER: S-EPMC3843107 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20131015 48
At least a third of the human population is infected with the intracellular parasite Toxoplasma gondii, which contributes significantly to the disease burden in immunocompromised and neutropenic hosts and causes serious congenital complications when vertically transmitted to the fetus. Genetic analyses have identified the Toxoplasma ROP18 Ser/Thr protein kinase as a major factor mediating acute virulence in mice. ROP18 is secreted into the host cell during the invasion process, and its catalytic ...[more]