Development of novel DNA vaccine for VEGF in murine cancer model.
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ABSTRACT:
SUBMITTER: Kyutoku M
PROVIDER: S-EPMC3843165 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Development of novel DNA vaccine for VEGF in murine cancer model.
Kyutoku Mariko M Nakagami Hironori H Koriyama Hiroshi H Tomioka Hideki H Nakagami Futoshi F Shimamura Munehisa M Kurinami Hitomi H Zhengda Pang P Jo Dong Hyun DH Kim Jeong Hun JH Takakura Nobuyuki N Morishita Ryuichi R
Scientific reports 20131129
We developed DNA vaccine for vascular endothelial growth factor (VEGF), which may provide the therapeutic option instead of anti-VEGF antibody, bevacizumab. Plasmid containing VEGF mini-gene was constructed in the insertion of B-cell epitope of Hepatitis B core protein [HBc-VEGF], which was an epitope carrier. High titer of anti-VEGF antibody was observed in BALB/c mice which were intramuscularly immunized with HBc-VEGF by electropolator. In mice inoculated with colon 26 cells, tumor volume and ...[more]
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