Ontology highlight
ABSTRACT:
SUBMITTER: Chenine AL
PROVIDER: S-EPMC3843658 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chenine Agnès-Laurence AL Wieczorek Lindsay L Sanders-Buell Eric E Wesberry Maggie M Towle Teresa T Pillis Devin M DM Molnar Sebastian S McLinden Robert R Edmonds Tara T Hirsch Ivan I O'Connell Robert R McCutchan Francine E FE Montefiori David C DC Ochsenbauer Christina C Kappes John C JC Kim Jerome H JH Polonis Victoria R VR Tovanabutra Sodsai S
PloS one 20131129 11
Standardized assays to assess vaccine and antiviral drug efficacy are critical for the development of protective HIV-1 vaccines and drugs. These immune assays will be advanced by the development of standardized viral stocks, such as HIV-1 infectious molecular clones (IMC), that i) express a reporter gene, ii) are representative of globally diverse subtypes and iii) are engineered to easily exchange envelope (env) genes for expression of sequences of interest. Thus far, a subtype B IMC backbone e ...[more]