Ontology highlight
ABSTRACT:
SUBMITTER: Meyer HH
PROVIDER: S-EPMC384367 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
The EMBO journal 20000501 10
The AAA-ATPase, p97/Cdc48p, has been implicated in many different pathways ranging from membrane fusion to ubiquitin-dependent protein degradation. Binding of the p47 complex directs p97 to act in the post-mitotic fusion of Golgi membranes. We now describe another binding complex comprising mammalian Ufd1 and Npl4. Yeast Ufd1p is required for ubiquitin-dependent protein degradation whereas yeast Npl4p has been implicated in nuclear transport. In rat liver cytosol, Ufd1 and Npl4 form a binary com ...[more]