Ontology highlight
ABSTRACT:
SUBMITTER: Walker AK
PROVIDER: S-EPMC3843686 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Walker Adam K AK Soo Kai Y KY Sundaramoorthy Vinod V Parakh Sonam S Ma Yi Y Farg Manal A MA Wallace Robyn H RH Crouch Peter J PJ Turner Bradley J BJ Horne Malcolm K MK Atkin Julie D JD
PloS one 20131129 11
In amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration, TAR DNA binding protein 43 (TDP-43) accumulates in the cytoplasm of affected neurons and glia, where it associates with stress granules (SGs) and forms large inclusions. SGs form in response to cellular stress, including endoplasmic reticulum (ER) stress, which is induced in both familial and sporadic forms of ALS. Here we demonstrate that pharmacological induction of ER stress causes TDP-43 to accumulate in the cytopl ...[more]