Ontology highlight
ABSTRACT:
SUBMITTER: Feng B
PROVIDER: S-EPMC3843694 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Feng Bin B Li Kai K Zhong Haixing H Ren Gui G Wang Hefei H Shang Yulong Y Bai Ming M Liang Jie J Wang Xin X Fan Daiming D
PloS one 20131129 11
RhoE, a novel member of the Rho protein family, is a key regulator of the cytoskeleton and cell migration. Our group has previously shown that RhoE as a direct target for HIF-1α and mediates hypoxia-induced epithelial to mesenchymal transition in gastric cancer cells. Therefore, we assumed that RhoE might play an important role in gastric cancer metastasis. In the present study, we have explored the role of RhoE expression in gastric cancer, cell invasion and metastasis, and the influence of Rho ...[more]