Ontology highlight
ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC3843819 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Lu Zhisheng Z Bergeron Julien R C JR Atkinson R Andrew RA Schaller Torsten T Veselkov Dennis A DA Oregioni Alain A Yang Yi Y Matthews Stephen J SJ Malim Michael H MH Sanderson Mark R MR
Open biology 20131113 11
The HIV-1 viral infectivity factor (Vif) neutralizes cell-encoded antiviral APOBEC3 proteins by recruiting a cellular ElonginB (EloB)/ElonginC (EloC)/Cullin5-containing ubiquitin ligase complex, resulting in APOBEC3 ubiquitination and proteolysis. The suppressors-of-cytokine-signalling-like domain (SOCS-box) of HIV-1 Vif is essential for E3 ligase engagement, and contains a BC box as well as an unusual proline-rich motif. Here, we report the NMR solution structure of the Vif SOCS-ElonginBC (EloB ...[more]