Ontology highlight
ABSTRACT:
SUBMITTER: Yang B
PROVIDER: S-EPMC3844094 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Yang Binxia B Janardhanan Rajiv R Vohra Pawan P Greene Eddie L EL Bhattacharya Santanu S Withers Sarah S Roy Bhaskar B Nieves Torres Evelyn C EC Mandrekar Jaywant J Leof Edward B EB Mukhopadhyay Debabrata D Misra Sanjay S
Kidney international 20130807 2
Venous neointimal hyperplasia (VNH) causes hemodialysis vascular access failure. Here we tested whether VNH formation occurs in part due to local vessel hypoxia caused by surgical trauma to the vasa vasorum of the outflow vein at the time of arteriovenous fistula placement. Selective targeting of the adventitia of the outflow vein at the time of fistula creation was performed using a lentivirus-delivered small-hairpin RNA that inhibits VEGF-A expression. This resulted in significant increase in ...[more]