Ontology highlight
ABSTRACT:
SUBMITTER: Li LY
PROVIDER: S-EPMC3844430 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Nature neuroscience 20130811 9
Cortical processing of sensory information begins with the transformation of thalamically relayed signals. We optogenetically silenced intracortical circuits to isolate thalamic inputs to layer 4 neurons and found that intracortical excitation linearly amplified thalamocortical responses underlying frequency and direction selectivity, with spectral range and tuning preserved, and prolonged the response duration. This signal pre-amplification and prolongation enhanced the salience of thalamocorti ...[more]