Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC3844532 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Zhang Huanchun H Taylor W Robert WR Joseph Giji G Caracciolo Valentina V Gonzales Donna M DM Sidell Neil N Seli Emre E Blackshear Perry J PJ Kallen Caleb B CB
Arteriosclerosis, thrombosis, and vascular biology 20130404 6
<h4>Objective</h4>We studied the expression and function of an mRNA-binding protein, zinc finger protein-36 (ZFP36), in vascular endothelial cells in vivo and in vitro. We tested the hypotheses that ZFP36 regulates inflammation in vascular endothelial cells and that it functions through direct binding to target cytokine mRNAs. We also tested whether ZFP36 inhibits nuclear factor-κB-mediated transcriptional responses in vascular endothelial cells.<h4>Approach and results</h4>ZFP36 was minimally e ...[more]