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Developmental disorders of the dentition: an update.

ABSTRACT: Dental anomalies are common congenital malformations that can occur either as isolated findings or as part of a syndrome. This review focuses on genetic causes of abnormal tooth development and the implications of these abnormalities for clinical care. As an introduction, we describe general insights into the genetics of tooth development obtained from mouse and zebrafish models. This is followed by a discussion of isolated as well as syndromic tooth agenesis, including Van der Woude syndrome (VWS), ectodermal dysplasias (EDs), oral-facial-digital (OFD) syndrome type I, Rieger syndrome, holoprosencephaly, and tooth anomalies associated with cleft lip and palate. Next, we review delayed formation and eruption of teeth, as well as abnormalities in tooth size, shape, and form. Finally, isolated and syndromic causes of supernumerary teeth are considered, including cleidocranial dysplasia and Gardner syndrome.

SUBMITTER: Klein OD

PROVIDER: S-EPMC3844689 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Developmental disorders of the dentition: an update.

Klein Ophir D OD Oberoi Snehlata S Huysseune Ann A Hovorakova Maria M Peterka Miroslav M Peterkova Renata R

American journal of medical genetics. Part C, Seminars in medical genetics 20131004 4

Dental anomalies are common congenital malformations that can occur either as isolated findings or as part of a syndrome. This review focuses on genetic causes of abnormal tooth development and the implications of these abnormalities for clinical care. As an introduction, we describe general insights into the genetics of tooth development obtained from mouse and zebrafish models. This is followed by a discussion of isolated as well as syndromic tooth agenesis, including Van der Woude syndrome (V ...[more]

PMID: 24124058

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