Ontology highlight
ABSTRACT:
SUBMITTER: Matsuda S
PROVIDER: S-EPMC3844774 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Matsuda Shuji S Giliberto Luca L Matsuda Yukiko Y McGowan Eileen M EM D'Adamio Luciano L D'Adamio Luciano L
The Journal of neuroscience : the official journal of the Society for Neuroscience 20080801 35
Genetic alterations of amyloid beta-peptide (Abeta) production caused by mutations in the Abeta precursor protein (APP) cause familial Alzheimer's disease (AD). Mutations in BRI2, a gene of undefined function, are linked to familial British and Danish dementias, which are pathologically and clinically similar to Alzheimer's disease. We report that BRI2 is a physiological suppressor of Abeta production. BRI2 restrict docking of gamma-secretase to APP and access of alpha- and beta-secretases to th ...[more]