Re-treatment of relapsed Paget's disease of bone with zoledronic acid: results from an open-label study.
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SUBMITTER: Reid IR
PROVIDER: S-EPMC3844974 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
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Re-treatment of relapsed Paget's disease of bone with zoledronic acid: results from an open-label study.
Reid Ian R IR Brown Jacques P JP Levitt Naomi N Román Ivorra José A JA Bachiller-Corral Javier J Ross Ian L IL Su Guoqin G Antunez-Flores Oscar O Aftring R Paul RP
BoneKEy reports 20131106
Six patients from the phase 3 trials of zoledronic acid in Paget's disease, who had received zoledronic acid initially and had subsequently relapsed, were entered into an open re-treatment study. Following re-treatment, each patient reached similar absolute nadirs of serum alkaline phosphatase to those recorded after their first dose. No significant adverse events were reported. It is concluded that, while re-treatment of Paget's disease with zoledronic acid is rarely needed, it is safe and effe ...[more]
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