Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation.
Ontology highlight
ABSTRACT:
SUBMITTER: Lai LP
PROVIDER: S-EPMC3845115 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation.
Lai Lick Pui LP Lilley Brendan N BN Sanes Joshua R JR McMahon Andrew P AP
Proceedings of the National Academy of Sciences of the United States of America 20131111 48
Liver kinase b1 (Lkb1) protein kinase activity regulates cell growth and cell polarity. Here, we show Lkb1 is essential for maintaining a balance between mitotic and postmitotic cell fates in development of the mammalian skeleton. In this process, Lkb1 activity controls the progression of mitotic chondrocytes to a mature, postmitotic hypertrophic fate. Loss of this Lkb1-dependent switch leads to a dramatic expansion of immature chondrocytes and formation of enchondroma-like tumors. Pathway analy ...[more]
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