Ontology highlight
ABSTRACT:
SUBMITTER: Wilker PR
PROVIDER: S-EPMC3845350 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Wilker Peter R PR Dinis Jorge M JM Starrett Gabriel G Imai Masaki M Hatta Masato M Nelson Chase W CW O'Connor David H DH Hughes Austin L AL Neumann Gabriele G Kawaoka Yoshihiro Y Friedrich Thomas C TC
Nature communications 20130101
The emergence of human-transmissible H5N1 avian influenza viruses poses a major pandemic threat. H5N1 viruses are thought to be highly genetically diverse both among and within hosts; however, the effects of this diversity on viral replication and transmission are poorly understood. Here we use deep sequencing to investigate the impact of within-host viral variation on adaptation and transmission of H5N1 viruses in ferrets. We show that, although within-host genetic diversity in haemagglutinin ( ...[more]