Ontology highlight
ABSTRACT:
SUBMITTER: Kuryavyi V
PROVIDER: S-EPMC3845372 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Kuryavyi Vitaly V Cahoon Laty A LA Seifert H Steven HS Patel Dinshaw J DJ
Structure (London, England : 1993) 20121018 12
Neisseria gonorrhoeae is an obligate human pathogen that can escape immune surveillance through antigenic variation of surface structures such as pili. A G-quadruplex-forming (G4) sequence (5'-G(3)TG(3)TTG(3)TG(3)) located upstream of the N. gonorrhoeae pilin expression locus (pilE) is necessary for initiation of pilin antigenic variation, a recombination-based, high-frequency, diversity-generation system. We have determined NMR-based structures of the all parallel-stranded monomeric and 5' end- ...[more]