Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice.
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ABSTRACT:
SUBMITTER: Jiang Y
PROVIDER: S-EPMC3845407 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice.
Jiang Yanjun Y Jin Jingling J Iakova Polina P Hernandez Julio Cesar JC Jawanmardi Nicole N Sullivan Emily E Guo Grace L GL Timchenko Nikolai A NA Darlington Gretchen J GJ
Mechanisms of ageing and development 20130902 9
Activation of xenobiotic metabolism pathways has been linked to lifespan extension in different models of aging. However, the mechanisms underlying activation of xenobiotic genes remain largely unknown. Here we showed that although farnesoid X receptor (FXR, Nr1h4) mRNA levels do not change significantly, FXR protein levels are elevated in the livers of the long-lived Little mice, leading to increased DNA binding activity of FXR. Hepatic FXR expression is sex-dependent in wild-type mice but not ...[more]
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