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Storable palladacycles for selective functionalization of alkyne-containing proteins.

ABSTRACT: We report the facile preparation of palladacycles as storable arylpalladium(II) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins.

SUBMITTER: Cheng G

PROVIDER: S-EPMC3845886 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Storable palladacycles for selective functionalization of alkyne-containing proteins.

Cheng Gang G Lim Reyna K V RK Li Nan N Lin Qing Q

Chemical communications (Cambridge, England) 20130801 60

We report the facile preparation of palladacycles as storable arylpalladium(II) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins. ...[more]

PMID: 23778852

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