Ontology highlight
ABSTRACT:
SUBMITTER: March ME
PROVIDER: S-EPMC3845901 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
March Michael E ME Long Eric O EO
Journal of immunology (Baltimore, Md. : 1950) 20110126 5
Cytotoxic lymphocytes kill target cells through polarized release of the content of lytic granules at the immunological synapse. In human NK cells, signals for granule polarization and for degranulation can be uncoupled: Binding of β(2) integrin LFA-1 to ICAM is sufficient to induce polarization but not degranulation, whereas CD16 binding to IgG triggers unpolarized degranulation. In this study, we investigated the basis for this difference. IL-2-expanded human NK cells were stimulated by incuba ...[more]