Ontology highlight
ABSTRACT:
SUBMITTER: Van Tine BA
PROVIDER: S-EPMC384690 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Van Tine Brian A BA Dao Luan D LD Wu Shwu-Yuan SY Sonbuchner Timothy M TM Lin Biing Yuan BY Zou Nianxiang N Chiang Cheng-Ming CM Broker Thomas R TR Chow Louise T LT
Proceedings of the National Academy of Sciences of the United States of America 20040312 12
Human papillomaviruses (HPVs) establish long-term infections in patients. The mechanism for extrachromosomal HPV DNA persistence in cycling cells is unknown. We show that HPV origin-containing plasmids partition as minichromosomes, attributable to an association of the viral origin recognition protein E2 with mitotic spindles. alpha-, beta-, and gamma-tubulins were pulled down with a tagged E2. The N-terminal transacting and C-terminal protein dimerization/DNA binding domains independently assoc ...[more]