Ontology highlight
ABSTRACT:
SUBMITTER: Kohyama M
PROVIDER: S-EPMC384717 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Kohyama Masako M Sugahara Daisuke D Sugiyama Shigeru S Yagita Hideo H Okumura Ko K Hozumi Nobumichi N
Proceedings of the National Academy of Sciences of the United States of America 20040310 12
In this study, we investigated the relationship between the expression levels of self-antigen and the function of self-reactive T cells in the periphery. To this end, we used two rat insulin promoter-ovalbumin (RIP-OVA) transgenic mice (RIP-OVA(high), RIP-OVA(low)) in which was produced only in pancreatic beta-islet cells. The OVA-producing transgenic mice were crossed to DO.11.10 (DO) mice expressing a T cell antigen receptor specific for OVA(323-339). The responsiveness of peripheral CD4(+) T ...[more]