Ontology highlight
ABSTRACT:
SUBMITTER: Hams E
PROVIDER: S-EPMC3847854 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20131028 11
The cellular composition of visceral adipose tissue (VAT) and release of cytokines by such cells within VAT has been implicated in regulating obesity and metabolic homeostasis. We show the importance of IL-25-responsive innate cells, which release the Th2 cytokine IL-13, in regulating weight and glucose homeostasis in mouse models of diet-induced obesity. Treating obese mice with IL-25 induces weight loss and improves glucose tolerance, and is associated with increased infiltration of innate lym ...[more]