A dominant connexin43 mutant does not have dominant effects on gap junction coupling in astrocytes.
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ABSTRACT:
SUBMITTER: Wasseff S
PROVIDER: S-EPMC3848784 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
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A dominant connexin43 mutant does not have dominant effects on gap junction coupling in astrocytes.
Wasseff Sameh S Abrams Charles K CK Scherer Steven S SS
Neuron glia biology 20101101 4
Dominant mutations in GJA1, the gene encoding the gap junction protein connexin43 (Cx43), cause oculodentodigital dysplasia (ODDD), a syndrome affecting multiple tissues, including the central nervous system (CNS). We investigated the effects of the G60S mutant, which causes a similar, dominant phenotype in mice (Gja1(Jrt/+)). Astrocytes in acute brain slices from Gja1(Jrt/+) mice transfer sulforhodamine-B comparably to that in their wild-type (WT) littermates. Further, astrocytes and cardiomyoc ...[more]
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