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Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.

ABSTRACT: Human Mycoplasma pneumoniae (MP) pneumonia is characterized by alveolar infiltration with neutrophils and lymphocytes and lymphocyte/plasma cell infiltrates in the peri-bronchovascular area (PBVA). No mouse model has been able to mimic the pathological features seen in human MP pneumonia, such as plasma cell-rich lymphocytic infiltration in PBVA. To figure out the mechanism for inflammation by MP infection using a novel mouse model that mimics human MP pneumonia, mice were pre-immunized intraperitoneally with Th2 stimulating adjuvant, alum, alone or MP extracts with an alum, followed by intratracheal challenge with MP extracts. The toll-like receptor-2, which is the major receptor for mycoplasma cell wall lipoproteins, was strongly up-regulated in alveolar macrophages in a latter group after the pre-immunization but prior to the intratracheal challenge. Those findings demonstrated that acceleration of innate immunity by antecedent antigenic stimulation can be an important positive-feedback mechanism in lung inflammation during MP pneumonia.

SUBMITTER: Saraya T

PROVIDER: S-EPMC3850488 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.

Saraya Takeshi T Nakata Koh K Nakagaki Kazuhide K Motoi Natsuki N Iihara Kuniko K Fujioka Yasunori Y Oka Teruaki T Kurai Daisuke D Wada Hiroo H Ishii Haruyuki H Taguchi Haruhiko H Kamiya Shigeru S Goto Hajime H

Results in immunology 20111111 1

Human Mycoplasma pneumoniae (MP) pneumonia is characterized by alveolar infiltration with neutrophils and lymphocytes and lymphocyte/plasma cell infiltrates in the peri-bronchovascular area (PBVA). No mouse model has been able to mimic the pathological features seen in human MP pneumonia, such as plasma cell-rich lymphocytic infiltration in PBVA. To figure out the mechanism for inflammation by MP infection using a novel mouse model that mimics human MP pneumonia, mice were pre-immunized intraper ...[more]

PMID: 24371556

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Project description:BackgroundThis study aimed to analyze the clinical features of children with lobar pneumonia caused by Mycoplasma pneumoniae (MP) infection, to explore the independent risk factors for bronchoscopic intervention in children with lobar pneumonia caused by MP infection. There is a lack of objective assessment tools to guide the use of bronchoscopy in clinical practice. For children with lobar pneumonia caused by MP infection, whether line shall be actively bronchoscope intervention therapy remains to be further defined. We also aimed to construct an early warning model of bronchoscopic intervention to provide an objective evaluation tool for clinicians.MethodsWe collected the clinical data of 533 children with lobar pneumonia caused by MP infection. The patients were divided into three groups according to the interventional indications for bronchoscopy and whether they were treated with bronchoscopic intervention, and the clinical features and prognosis of the three groups were compared. A binary logistic regression analysis was performed on the indicators with a significance value of P<0.05, which we retrieved from the comparative analysis between the first two groups to uncover the independent risk factors and regression equations concerning bronchoscopic intervention. The regression coefficient (β) of our regression model was then used to score related values in the model to construct a predictive scoring model of bronchoscopic intervention for the treatment of children with lobar pneumonia caused by MP infection.ResultsChildren with lobar pneumonia caused by MP infection who demonstrated absolute indications for bronchoscopy exhibited more severe clinical manifestations, and children without absolute indications for bronchoscopy had a better prognosis even without bronchoscopic intervention. To establish our early warning model of bronchoscopic intervention for children with lobar pneumonia caused by MP infection, we used the following indices: C-reactive protein ≥20.94 mg/L (β1=2.253) received 3 points, while a fever duration before bronchoscopy ≥6.5 d (β2=1.424), lactate dehydrogenase ≥461.5 U/L (β3=1.246), or fever (β4=1.223) each received 2 points, and the complication of pleural effusion (β5=0.841) received 1 point, for a total possible score of 10 points.ConclusionsWhen the score for the children with lobar pneumonia caused by MP infection was ≥6, the possibility of bronchoscopic intervention for treatment was >80%. The higher the score, the greater the possibility of bronchoscopic intervention.

Dataset Information

Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.

Publications

Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.

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