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Heart fatty acid binding protein and A?-associated Alzheimer's neurodegeneration.

ABSTRACT:

Background

Epidemiological and molecular findings suggest a relationship between Alzheimer's disease (AD) and dyslipidemia, although the nature of this association is not well understood.

Results

Using linear mixed effects models, we investigated the relationship between CSF levels of heart fatty acid binding protein (HFABP), a lipid binding protein involved with fatty acid metabolism and lipid transport, amyloid-? (A?), phospho-tau, and longitudinal MRI-based measures of brain atrophy among 295 non-demented and demented older individuals. Across all participants, we found a significant association of CSF HFABP with longitudinal atrophy of the entorhinal cortex and other AD-vulnerable neuroanatomic regions. However, we found that the relationship between CSF HABP and brain atrophy was significant only among those with low CSF A?1-42 and occurred irrespective of phospho-tau181p status.

Conclusions

Our findings indicate that A?-associated volume loss occurs in the presence of elevated HFABP irrespective of phospho-tau. This implicates a potentially important role for fatty acid binding proteins in Alzheimer's disease neurodegeneration.

SUBMITTER: Desikan RS

PROVIDER: S-EPMC3850652 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Publications

Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration.

Desikan Rahul S RS Thompson Wesley K WK Holland Dominic D Hess Christopher P CP Brewer James B JB Zetterberg Henrik H Blennow Kaj K Andreassen Ole A OA McEvoy Linda K LK Hyman Bradley T BT Dale Anders M AM

Molecular neurodegeneration 20131002

<h4>Background</h4>Epidemiological and molecular findings suggest a relationship between Alzheimer's disease (AD) and dyslipidemia, although the nature of this association is not well understood.<h4>Results</h4>Using linear mixed effects models, we investigated the relationship between CSF levels of heart fatty acid binding protein (HFABP), a lipid binding protein involved with fatty acid metabolism and lipid transport, amyloid-β (Aβ), phospho-tau, and longitudinal MRI-based measures of brain at ...[more]

PMID: 24088526

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