Elderly subset analysis of randomized phase III study comparing pemetrexed plus carboplatin with docetaxel plus carboplatin as first-line treatment for patients with locally advanced or metastatic non-small cell lung cancer.

ABSTRACT:

Background

Many physicians consider platinum-doublet chemotherapy inappropriate for elderly patients, regardless of their medical fitness.

Objective

This was a retrospective subgroup analysis of data from a multicenter, randomized, phase III clinical trial evaluating pemetrexed + carboplatin versus docetaxel + carboplatin in elderly chemo-naive patients with advanced, nonsquamous non-small cell lung cancer (NSCLC).

Methods

Data from elderly patients (aged ≥65 years and ≥70 years) were evaluated using the same statistical methods as those used in patients aged <70 years and qualified intent-to-treat (Q-ITT) populations. The primary objective of the clinical trial was comparison of pemetrexed + carboplatin with docetaxel + carboplatin in terms of survival without grade

SUBMITTER: Pereira JR 

PROVIDER: S-EPMC3851706 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature