Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival.

ABSTRACT:

Background

Alterations in lipid metabolism are inherent to the metabolic transformations that support tumorigenesis. The relationship between the synthesis, storage and use of lipids and their importance in cancer is poorly understood. The human group X secreted phospholipase A2 (hGX sPLA2) releases fatty acids (FAs) from cell membranes and lipoproteins, but its involvement in the regulation of cellular FA metabolism and cancer is not known.

Results

Here we demonstrate that hGX sPLA2 induces lipid droplet (LD) formation in invasive breast cancer cells, stimulates their proliferation and prevents their death on serum deprivation. The effects of hGX sPLA2 are shown to be dependent on its enzymatic activity, are mimicked by oleic acid and include activation of protein kinase B/

SUBMITTER: Pucer A 

PROVIDER: S-EPMC3852912 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature