Ovarian dual oxidase (Duox) activity is essential for insect eggshell hardening and waterproofing.
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ABSTRACT:
SUBMITTER: Dias FA
PROVIDER: S-EPMC3853258 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
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Ovarian dual oxidase (Duox) activity is essential for insect eggshell hardening and waterproofing.
Dias Felipe A FA Gandara Ana Caroline P AC Queiroz-Barros Fernanda G FG Oliveira Raquel L L RL Sorgine Marcos H F MH Braz Glória R C GR Oliveira Pedro L PL
The Journal of biological chemistry 20131030 49
In insects, eggshell hardening involves cross-linking of chorion proteins via their tyrosine residues. This process is catalyzed by peroxidases at the expense of H2O2 and confers physical and biological protection to the developing embryo. Here, working with Rhodnius prolixus, the insect vector of Chagas disease, we show that an ovary dual oxidase (Duox), a NADPH oxidase, is the source of the H2O2 that supports dityrosine-mediated protein cross-linking and eggshell hardening. RNAi silencing of D ...[more]
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