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New diterpenoids from soft coral Sarcophyton ehrenbergi.

ABSTRACT: Continuing chemical investigation on the acetone extracts of the soft coral Sarcophyton ehrenbergi collected off the coast of San-hsian-tai, Taitong County, Taiwan led to the isolation of two new diterpenoids, ehrenbergol C and acetyl ehrenberoxide B (1 and 2). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, in vitro tests show that compounds 1 and 2 displayed antiviral activity towards human cytomegalovirus, with EC50 of 20 and 8.0 µg/mL, respectively.

SUBMITTER: Wang SK

PROVIDER: S-EPMC3853730 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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New diterpenoids from soft coral Sarcophyton ehrenbergi.

Wang Shang-Kwei SK Hsieh Mu-Keng MK Duh Chang-Yih CY

Marine drugs 20131030 11

Continuing chemical investigation on the acetone extracts of the soft coral Sarcophyton ehrenbergi collected off the coast of San-hsian-tai, Taitong County, Taiwan led to the isolation of two new diterpenoids, ehrenbergol C and acetyl ehrenberoxide B (1 and 2). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, in vitro tests show that compounds 1 and 2 displayed antiviral activity towards human cytomegalovirus, with EC50 of 20 and 8. ...[more]

PMID: 24177676

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