Ontology highlight
ABSTRACT:
SUBMITTER: Yin X
PROVIDER: S-EPMC3854245 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120426 8
Tissue transglutaminase (type II, TG2) has long been postulated to directly promote skeletal matrix calcification and play an important role in ossification. However, limited information is available on the expression, function and modulating mechanism of TG2 during osteoblast differentiation and mineralization. To address these issues, we cultured the well-established human osteosarcoma cell line SAOS-2 with osteo-inductive conditioned medium and set up three time points (culture days 4, 7, and ...[more]