Ontology highlight
ABSTRACT:
SUBMITTER: Dayan GH
PROVIDER: S-EPMC3854882 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Dayan Gustavo H GH Garbes Pedro P Noriega Fernando F Izoton de Sadovsky Ana Daniela AD Rodrigues Patricia Marques PM Giuberti Camila C Dietze Reynaldo R
The American journal of tropical medicine and hygiene 20131104 6
Immunogenicity and safety of a recombinant, live-attenuated, tetravalent dengue disease vaccine (CYD-TDV) was evaluated in children/adolescents in Brazil. In this observer-blind, placebo-controlled, phase II single-center study, children/adolescents (ages 9-16 years) were randomized to receive CYD-TDV or placebo at 0, 6, and 12 months. Immunogenicity was assessed using a 50% plaque neutralization test. Overall, 150 participants were enrolled (CYD-TDV: N = 100; placebo: N = 50). Injection site pa ...[more]